ABSTRACT
This paper describes a case of COVID-19-associated cavernous sinus thrombosis complicated by panophthalmitis, orbital cellulitis and necrotic purulent complications in other maxillofacial structures. In addition, we present the results of the pathomorphological study of orbital wall and orbital soft-tissue material excised during surgery. The pathomorphological findings in the orbital tissues included signs of a chronic inflammatory process with mostly lymphocyte infiltration, a proliferative component and development of mixed-type thrombi. © Oripov O. I., Bilalov E. N., Israilov R. I., Umarov R. Z., Bilalov B. E., Khudaibergenov G. U., 2022.
ABSTRACT
Researchers have shown that SARS-CoV and MERS-CoV can also cause liver damage in an infected organism, but the mechanisms of injury are poorly understood. In this study, pathomorphological changes in the liver during coronavirus infection in pregnant women were studied. As material, the liver was studied at autopsy of maternal mortality from 33 coronaviruses conducted at RCPA (Republican Center for Pathological Anatomy) between 2020 and 2021. Morphological examinations of liver tissue showed that the development of various pathomorphological changes in the liver was also observed depending on the periods of coronavirus infection. In the exudative period of the coronavirus is observed a strong process of circulating in the liver, swelling, destruction and bleeding of interstitial tissue, the development of protein and hydropic dystrophy in the liver parenchyma, i.e. hepatocytes. In the second proliferative inflammatory period of the disease, there is an increase in lymphoid infiltration along the portal pathways of the liver, myxomatous metaplasia of Kupffer cells, proliferation and proliferation of fibroblasts, growth of connective tissue, portal pathways of fibrous structures, periphery and even sinusoidal wall.